Misoprostol is used for the prevention of NSAID-induced gastric ulcers. It acts upon gastric parietal cells, inhibiting the secretion. NSAID-Induced Ulcer. Prophylaxis. mcg PO q6hr with food; may be decreased to mcg q6hr if higher dose is not tolerated; last dose to be administered. Postgrad Med J. ;64 Suppl The therapeutic efficacy of misoprostol in peptic ulcer disease. Watkinson G(1), Hopkins A, Akbar FA.
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Similarly, while in volunteers pretreatment with misoprostol is able to protect the gastric mucosa from alcohol damage, there is little clinical evidence to support improved ulcer healing in the patient who abuses alcohol. Obstetrics and Gynecology. Dosage adjustment s may be required; however, no specific source
have been suggested. The serum concentration of Misoprostol can be decreased when it is combined with Magnesium hydroxide. Arachidonic acid hydroperoxide. Misoprostol is well tolerated--a dose related, here
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occurred in a small proportion of patients but only rarely enforced withdrawal. Arachidonic acid 5-hydroperoxide.